Cardiovascular, Pulmonary and Renal Pathology Latent Transforming Growth Factor- -Binding Protein-4 Regulates Transforming Growth Factor- 1 Bioavailability for Activation by Fibrogenic Lung Fibroblasts in Response to Bleomycin
نویسندگان
چکیده
From the Department of Pathology, Division of Molecular and Cellular Pathology,* the BioMatrix Engineering and Regenerative Medicine Center, and the Departments of Pediatrics (Pulmonary Division), Cell Biology and Pathology, University of Alabama at Birmingham, Birmingham, Alabama; the Departments of Virology and Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; and the Department of Cell Biology, New York University School of Medicine, New York, New York
منابع مشابه
Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis.
Fibroblasts consist of heterogeneous subpopulations that have distinct roles in fibrotic responses. Previously we reported enhanced proliferation in response to fibrogenic growth factors and selective activation of latent transforming growth factor (TGF)-beta in fibroblasts lacking cell surface expression of Thy-1 glycoprotein, suggesting that Thy-1 modulates the fibrogenic potential of fibrobl...
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